PPAR and immune system—what do we know? | 健康食品資訊網

由XZhang著作·2002·被引用163次—Peroxisomeproliferator-activatedreceptors(PPARs)belongtothenuclearsteroidreceptorsuperfamily.Originally,thereceptorswereidentifiedas ...

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear steroid receptor superfamily. Originally, the receptors were identified as critical controllers for several key enzymes that catalyze the oxidation of fatty acids. PPARs consist of three members: PPAR-α, PPAR-β/δ, and PPAR-γ. Among them, PPAR-γ is essential for controlling thermogenesis and adipocyte differentiation. The ligands for PPAR-γ include 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2)—a metabolite from the prostaglandin synthesis pathway, and “glitazones”—drugs utilized in the treatment of patients with diabetes. The precursors for prostaglandins are fatty acids consumed from diet and these precursors have long been postulated to have a regulatory role in immune functions. Emerging evidence indicates that PPAR-γ and its ligands are indeed important for the modulation of immune and inflammatory reactions. In this review, we will spotlight the molecular mechanisms of receptor/ligand functi...